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Updated: May 3, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Stroke risk after transcatheter aortic valve replacement in patients with carotid stenosis: A systematic review and
Fernando Garagoli1, Juan Guido Chiabrando2, Ignacio Miguel Seropian3
1Department of Cardiology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Insights
Severe carotid artery stenosis (CAS ≥70%) increases stroke risk after transcatheter aortic valve replacement (TAVR). Mild CAS (CAS ≥50%) did not significantly raise stroke or mortality risks following TAVR procedures.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Neurology
Background:
- Stroke is a significant complication associated with transcatheter aortic valve replacement (TAVR).
- Patients undergoing TAVR often present with comorbidities, including carotid artery stenosis (CAS).
Conclusions:
- Carotid artery stenosis of 70% or greater is associated with a higher risk of stroke or TIA post-TAVR.
- No significant increase in mortality was found for patients with CAS undergoing TAVR.
Background:
Stroke is a feared complication of transcatheter aortic valve replacement (TAVR). Patients undergoing TAVR typically have multiple comorbidities, such as carotid artery stenosis (CAS). We conducted the present meta-analysis to determine the risk of stroke and mortality following TAVR in patients with CAS.
Methods:
We searched PubMed/Medline, Scopus, ScienceDirect, and Cochrane Clinical Trials databases for clinical studies that compared CAS ≥50% and CAS ≥70% versus non-CAS TAVR population. The endpoints included the 30-day incidence of stroke or transient ischemic attack (TIA) and 30-day all-cause of mortality.
Results:
We identified seven studies that included 12,418 patients in the CAS group and 102,316 in the control group. CAS ≥50% was not associated with an increased risk of 30-day stroke or TIA after TAVR [risk ratio (RR): 1.38; 95% confidence interval (95% CI): 0.95-2.02; p = 0.09]. However, patients with CAS ≥70% had an increased risk of stroke or TIA (RR: 1.43; 95% CI: 1.02-2.01; p = 0.04). No difference in 30-day all-cause mortality was observed between CAS ≥50% or CAS ≥70% and control groups (RR: 1.09; 95% CI: 0.79-1.52; p = 0.59 and RR: 1.11; 95% CI: 0.85-1.45; p = 0.43, respectively).
Conclusions:
CAS ≥70% was associated with an increased risk of stroke or TIA following TAVR compared with patients without CAS.
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