Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ribosome Profiling02:24

Ribosome Profiling

3.5K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.5K
Leaky Scanning02:28

Leaky Scanning

5.1K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Allele-specific splicing modulates protein isoforms and Alzheimer's disease risk.

Genome research·2026
Same author

Characterization of Mitochondrial Double-Stranded RNA Levels in Non-Small Cell Lung Carcinoma.

Cancer research communications·2026
Same author

ADAR-GPT: Learning the language of the epitranscriptome.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Allele-specific splicing modulates protein isoforms and Alzheimer's risk.

bioRxiv : the preprint server for biology·2026
Same author

Allele-specific alternative polyadenylation links noncoding genetic variation to Alzheimer's disease risk.

bioRxiv : the preprint server for biology·2026
Same author

Meta-analysis of genetic regulation of RNA editing in the human brain identifies new genes underlying neurological disease.

medRxiv : the preprint server for health sciences·2025

Related Experiment Video

Updated: Jun 27, 2025

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

4.2K

Navigating the landscape of epitranscriptomics and host immunity.

Elaine Huang1, Clara Frydman1, Xinshu Xiao2,3,4,5

  • 1Bioinformatics Interdepartmental Program, University of California, Los Angeles, California 90095, USA.

Genome Research
|May 3, 2024
PubMed
Summary

RNA modifications, or epitranscriptomic marks, regulate immune responses by controlling immunogenic RNAs and immune genes. Targeting RNA modification enzymes shows promise for cancer immunotherapy.

More Related Videos

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
14:40

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

3.2K
Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

6.8K

Related Experiment Videos

Last Updated: Jun 27, 2025

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

4.2K
Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
14:40

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

3.2K
Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

6.8K

Area of Science:

  • Molecular Biology
  • Immunology
  • Genetics

Background:

  • RNA modifications, known as epitranscriptomic marks, are chemical alterations to nucleotides.
  • These marks play crucial roles in various biological processes, particularly in host immune defense.

Purpose of the Study:

  • To provide an overview of recent findings on RNA modifications in immunity.
  • To categorize the functions of immune-related RNA modifications.
  • To discuss methods for identifying RNA modifications and their substrates.

Main Methods:

  • Literature review of recent research findings.
  • Discussion of genome-wide identification techniques for RNA modifications.
  • Exploration of cancer immunotherapy strategies targeting RNA modification enzymes.

Main Results:

  • Immune-related RNA modifications regulate immunogenic RNAs, innate immune genes, and adaptive immunity.
  • Genome-wide methods enable identification of RNA modifications and their substrates.
  • Targeting RNA modification enzymes is a developing strategy in cancer immunotherapy.

Conclusions:

  • RNA modifications are integral to immune system function.
  • Further research into RNA modifications and their targeting holds potential for therapeutic applications, especially in cancer immunotherapy.