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Impulse oscillometry in the diagnosis of cough variant asthma in children

Chunyu Tian1, Shiqiu Xiong1, Shuo Li1

  • 1Department of Allergy, Children's Hospital Affiliated with the Capital Institute of Pediatrics, No.2 Yabao Road, Chaoyang District, Beijing, 100020, China.

BMC Pediatrics
|May 3, 2024
PubMed

Insights

Impulse oscillometry (IOS) can help diagnose cough variant asthma (CVA) in children. Combining IOS parameters before and after bronchodilation significantly improves diagnostic accuracy for CVA.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Diagnostics
  • Asthma Research

Background:

  • Cough variant asthma (CVA) is a common cause of chronic cough in children, posing diagnostic challenges.
  • Accurate diagnosis of CVA is crucial for effective management and treatment in pediatric populations.

Purpose of the Study:

  • To evaluate the diagnostic utility of impulse oscillometry (IOS) pulmonary function tests in children with CVA.
  • To assess the effectiveness of bronchodilation (BD) tests in conjunction with IOS for CVA diagnosis.

Main Methods:

  • Children aged 4-12 with CVA underwent IOS and BD tests; a control group of healthy children was included.
  • Pre- and post-bronchodilation IOS parameters were recorded and analyzed.
  • Receiver operating characteristic (ROC) curves and area under the curve (AUC) were used to determine diagnostic discriminatory potential.

Main Results:

  • Children with CVA showed significantly different baseline IOS parameters compared to controls.
  • IOS parameters improved significantly after bronchodilation in the CVA group.
  • Combinations of pre-BD and BD-induced changes in IOS parameters (pre-Z5%pred+△Z5% and pre-R5%pred+△R5%) yielded the highest diagnostic accuracy (AUC 0.920 and 0.898).

Conclusions:

  • Children with CVA exhibit distinct IOS parameter profiles compared to healthy children.
  • Changes in IOS parameters following bronchodilation offer valuable diagnostic insights for CVA.
  • Combining multiple IOS parameters enhances the accuracy of CVA diagnosis in pediatric patients.
Abstract

Keywords:
ChildrenCough variant asthmaDiagnosisImpulse oscillometry

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