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Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
Targeting histone deacetylases in head and neck squamous cell carcinoma: molecular mechanisms and therapeutic targets
Mengchen Xu1, Yiming Hou1, Na Li2,3
1Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Department of Orthodontics, School and Hospital of Stomatology, Shandong Provincial Clinical Research Center for Oral Diseases, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Abstract:
The onerous health and economic burden associated with head and neck squamous cell carcinoma (HNSCC) is a global predicament. Despite the advent of novel surgical techniques and therapeutic protocols, there is an incessant need for efficacious diagnostic and therapeutic targets to monitor the invasion, metastasis and recurrence of HNSCC due to its substantial morbidity and mortality. The differential expression patterns of histone deacetylases (HDACs), a group of enzymes responsible for modifying histones and regulating gene expression, have been demonstrated in neoplastic tissues. However, there is limited knowledge regarding the role of HDACs in HNSCC. Consequently, this review aims to summarize the existing research findings and explore the potential association between HDACs and HNSCC, offering fresh perspectives on therapeutic approaches targeting HDACs that could potentially enhance the efficacy of HNSCC treatment. Additionally, the Cancer Genome Atlas (TCGA) dataset, CPTAC, HPA, OmicShare, GeneMANIA and STRING databases are utilized to provide supplementary evidence on the differential expression of HDACs, their prognostic significance and predicting functions in HNSCC patients.
Insights
Histone deacetylases (HDACs) show altered expression in head and neck squamous cell carcinoma (HNSCC). This review explores HDACs as potential therapeutic targets to improve HNSCC treatment efficacy and patient outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Head and neck squamous cell carcinoma (HNSCC) presents a significant global health and economic challenge.
- Existing treatments for HNSCC have limitations in managing invasion, metastasis, and recurrence, necessitating new therapeutic targets.
Purpose of the Study:
- To review current research on the role of histone deacetylases (HDACs) in HNSCC.
- To explore the potential of HDACs as diagnostic and therapeutic targets for HNSCC.
- To offer new perspectives on HDAC-targeted therapies to improve HNSCC treatment outcomes.
Main Methods:
- Comprehensive literature review of HDACs in cancer.
- Analysis of publicly available datasets including TCGA, CPTAC, HPA, OmicShare, GeneMANIA, and STRING.
- Examination of differential expression, prognostic significance, and predictive functions of HDACs in HNSCC.
Main Results:
- Histone deacetylases (HDACs) exhibit differential expression patterns in neoplastic tissues.
- Evidence suggests a potential association between HDACs and HNSCC, impacting gene expression and cellular processes.
- Bioinformatic analyses provide data on HDAC expression and prognostic value in HNSCC patients.
Conclusions:
- HDACs represent a promising area for developing novel therapeutic strategies in HNSCC.
- Targeting HDACs could potentially enhance the efficacy of current HNSCC treatments.
- Further research into HDACs may lead to improved diagnostic and prognostic tools for HNSCC.
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