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Risk Factors of Age-Related Macular Degeneration in a Population-Based Study: Results from SHIP-TREND-1 (Study of Health in Pomerania-TREND-1)

  • 0Department of Ophthalmology, University Medicine Greifswald, Greifswald, Germany.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research +

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May 4, 2024

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May 4, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Age-related macular degeneration (AMD) risk increases with age, HDL cholesterol, fT3, and lower education. In men, BMI and smoking also elevate AMD risk, highlighting metabolic factors.

Area Of Science

  • Ophthalmology
  • Epidemiology
  • Gerontology

Background

  • Age-related macular degeneration (AMD) is a leading cause of vision loss in older adults.
  • The Study of Health in Pomerania (SHIP) investigates health in the general population.
  • This study identifies modifiable risk factors for AMD progression.

Purpose Of The Study

  • To determine modifiable risk factors associated with AMD in the SHIP-TREND cohort.
  • To understand AMD risk factors for developing therapeutic strategies.
  • To investigate the link between metabolic factors and AMD.

Main Methods

  • Analysis of data from the first SHIP-TREND follow-up (2016-2019).
  • Fundus photography and AMD grading using the Rotterdam classification system.
  • Inclusion of 1418 participants aged 28-89 years with gradable fundus photographs.

Main Results

  • AMD risk correlates positively with age, HDL cholesterol, fT3, and low educational level.
  • In males, Body Mass Index (BMI) and cigarette smoking are associated with increased AMD risk.
  • Identified significant associations between AMD and various metabolic and lifestyle factors.

Conclusions

  • Age, metabolic factors (HDL, fT3), education, BMI, and smoking are key risk factors for AMD.
  • Therapeutic strategies should consider these identified metabolic pathways.
  • Modifying these risk factors may help slow early AMD progression.