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Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
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Mild cognitive impairment in pemphigus
Leila Ghadirzade Arani1, Soroor Advani2, Ghazal Mardani1
1Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
International Journal of Dermatology
|May 4, 2024
Summary
Pemphigus patients show higher rates of mild cognitive impairment (MCI) and lower cognitive test scores, particularly in executive functions. Higher education may reduce MCI risk in these individuals.
Area of Science:
- Neuroscience
- Dermatology
- Autoimmune Diseases
Background:
- Pemphigus is an autoimmune blistering disease linked to dementia.
- Mild cognitive impairment (MCI) often precedes dementia.
- Previous studies suggest a pemphigus-dementia association.
Purpose of the Study:
- To determine the prevalence of MCI in pemphigus patients.
- To compare cognitive function in pemphigus patients versus a control group.
Main Methods:
- A case-control study involving 80 pemphigus patients and 80 controls.
- Cognitive function assessed using the Persian version of the Montreal Cognitive Assessment (MoCA) test.
- Demographic, disease, and medication data collected.
Main Results:
- MCI was more frequent in pemphigus patients (55%) than controls (37.5%).
- Pemphigus patients had lower overall MoCA scores and executive function scores.
- Increased education level was associated with a reduced likelihood of MCI.
Conclusions:
- Pemphigus patients exhibit a higher incidence of MCI and impaired executive function.
- The MoCA test can aid in identifying pemphigus patients with MCI for early intervention.
- Higher education may be a protective factor against MCI in pemphigus.
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