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Updated: Jun 27, 2025

Glass-Based Devices to Generate Drops and Emulsions

Glass-Based Devices to Generate Drops and Emulsions

Published on: April 5, 2022

Engineered shapes using electrohydrodynamic atomization for an improved drug delivery.

Deng-Guang Yu¹, Wenjian Gong¹, Jianfeng Zhou¹

¹School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology

|May 4, 2024

Summary

This summary is machine-generated.

Electrohydrodynamic atomization (EHDA) techniques enable precise control over micro- and nano-product shapes, significantly impacting drug release profiles. This review explores how various EHDA-generated shapes, like nanofibers and nanoparticles, can be tailored for diverse drug delivery applications.

Keywords:

controlled release drug delivery electrospinning electrospraying multi‐chamber structures shapes

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Area of Science:

Materials Science and Engineering
Nanotechnology
Pharmaceutical Sciences

Background:

The functional performance of micro- and nano-products is heavily influenced by their shape, a factor often overlooked.
Electrohydrodynamic atomization (EHDA) techniques, including electrospinning and electrospraying, offer facile methods for controlling product morphology.

Purpose of the Study:

To review the diverse shapes of micro- and nano-products generated by EHDA.
To explore how these shapes can be utilized to modify and optimize drug release profiles for various therapeutic needs.

Main Methods:

Review of literature on electrohydrodynamic atomization (EHDA) techniques (electrospinning, electrospraying).
Analysis of various micro- and nano-product shapes generated by EHDA, including linear nanofibers, round micro-/nano-particles, and beads-on-a-string hybrids.
Categorization of shapes and their correlation with drug release patterns (pulsatile, sustained, biphasic, delayed, pH-sensitive).

Main Results:

EHDA techniques can produce a range of well-defined micro- and nano-product shapes.
Specific shapes, such as linear nanofibers and spherical nanoparticles, can be engineered to achieve desired drug release kinetics.
The organization and internal structure of electrospun nanofibers, in addition to their overall shape, are crucial for advanced drug delivery systems.

Conclusions:

Tailoring the shapes of micro- and nano-products using EHDA is a powerful strategy for controlling drug release.
Future research should focus on nanoscale shape-performance relationships to advance drug delivery technologies.
Integrating shape, size, and internal structure analysis will drive innovation in novel drug delivery systems.