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Updated: Jun 27, 2025
06:24
Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
Published on: April 11, 2025
301
LINC00152: Potential driver oncogene in pan-cancer
Wei Xu1,2, Huiting Li1,2, Ziyao Wang3
1NHC Key Laboratory of Carcinogenesis, National Clinical Research Center for Geriatric Disorders, Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Department of oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wiley Interdisciplinary Reviews. RNA
|May 4, 2024
Summary
Long noncoding RNA 152 (LINC00152) drives tumor progression by promoting malignancy, chemoresistance, and immune escape. This review details LINC00152
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long noncoding RNAs (lncRNAs) are key regulators with diverse cellular functions.
- LINC00152, transcribed from chromosome 2p11.2, is implicated in various cancer types.
- Its roles in promoting tumor malignancy, chemoresistance, and immune escape are increasingly recognized.
Purpose of the Study:
- To systematically review upstream regulatory factors influencing LINC00152 expression in tumors.
- To consolidate current understanding of LINC00152 functions and mechanisms in pan-cancer.
- To highlight LINC00152's potential as a driver oncogene and biomarker.
Main Methods:
- Systematic literature review of studies on LINC00152 regulation and function.
- Analysis of LINC00152's involvement in molecular signaling networks (epigenetic, protein interactions, ceRNA).
- Review of LINC00152's role as a driver oncogene and biomarker across various cancers.
Main Results:
- LINC00152 expression is modulated by transcription factors and DNA hypomethylation.
- It influences tumor progression through oncogenic phenotypes, chemoresistance, and immune evasion.
- LINC00152 participates in complex regulatory networks, impacting cancer development.
Conclusions:
- LINC00152 is a significant oncogenic lncRNA with critical roles in diverse cancers.
- Understanding its upstream regulation and downstream mechanisms is crucial for therapeutic strategies.
- LINC00152 holds promise as a pan-cancer biomarker and therapeutic target.
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