Bias-reduced neural networks for parameter estimation in quantitative MRI
Related Experiment Video
Updated: Jun 2, 2026
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
Andrew Mao1,2,3, Sebastian Flassbeck1,2, Jakob Assländer1,2
1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.
Purpose:
To develop neural network (NN)-based quantitative MRI parameter estimators with minimal bias and a variance close to the Cramér-Rao bound.
Theory And Methods:
We generalize the mean squared error loss to control the bias and variance of the NN's estimates, which involves averaging over multiple noise realizations of the same measurements during training. Bias and variance properties of the resulting NNs are studied for two neuroimaging applications.
Results:
In simulations, the proposed strategy reduces the estimates' bias throughout parameter space and achieves a variance close to the Cramér-Rao bound. In vivo, we observe good concordance between parameter maps estimated with the proposed NNs and traditional estimators, such as nonlinear least-squares fitting, while state-of-the-art NNs show larger deviations.
Conclusion:
The proposed NNs have greatly reduced bias compared to those trained using the mean squared error and offer significantly improved computational efficiency over traditional estimators with comparable or better accuracy.
