Exploring the association between isotretinoin and sexual dysfunction: a comprehensive scoping review

Area of Science:

• Dermatology
• Pharmacology
• Sexual Medicine

Background:

• Previous studies suggest a potential link between isotretinoin use and sexual dysfunction.
• This association has not been systematically reviewed in the literature to date.

Purpose of the Study:

• To conduct a scoping review evaluating the methodology and quality of studies on isotretinoin and sexual dysfunction.
• To examine the varied definitions of sexual dysfunction employed in existing research.

Main Methods:

• A scoping review methodology was utilized to identify relevant peer-reviewed research articles.
• Extensive search terms included 'isotretinoin', 'sexual dysfunction', and related terms for male and female sexual health issues.

Main Results:

• 55 manuscripts were reviewed (8 animal, 46 human studies with 2420 patients).
• Over half of the studies (54%) reported neutral or beneficial effects of isotretinoin on sexual function.
• The majority of studies (89%) were classified as low-level evidence (Oxford EBM Level 4).

Conclusions:

• The current evidence for a link between isotretinoin and sexual dysfunction is very weak.
• Inconsistent definitions of sexual dysfunction hinder comparative analysis and understanding.
• Standardization of sexual dysfunction definitions and causality frameworks are recommended for future research.