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The Chinese keratoconus (CKC) cohort study.

Kaili Yang1, Xiaotian Liu2, Liyan Xu1

  • 1Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, People's Hospital of Zhengzhou University, Henan University People's Hospital, 7 Weiwu Road, Zhengzhou, Henan, China.

European Journal of Epidemiology
|May 4, 2024
PubMed
Summary

The Chinese keratoconus (CKC) cohort study investigates gene-environment interactions to prevent keratoconus progression. This longitudinal study in China collected extensive patient data, establishing a foundation for future research.

Keywords:
ChineseCohort studyGene‒environment interactionsKeratoconusProgression

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Area of Science:

  • Ophthalmology
  • Genetics
  • Epidemiology

Background:

  • Keratoconus (KC) is a progressive eye condition.
  • Understanding gene-environment interactions is crucial for preventing KC progression.
  • The Chinese population presents unique genetic and environmental factors relevant to KC.

Purpose of the Study:

  • To establish a population-based longitudinal cohort study in China focusing on keratoconus.
  • To investigate the impact of gene-environment interactions on keratoconus progression.
  • To lay the groundwork for developing strategies to prevent KC progression.

Main Methods:

  • Established the Chinese Keratoconus (CKC) cohort, a hospital-based, dynamic study.
  • Enrolled 1114 KC patients in Zhengzhou, China (January 2019 - June 2023).
  • Collected demographic, lifestyle, clinical, genetic, and environmental data via questionnaires and examinations.

Main Results:

  • The CKC cohort includes a clinical database and biobanks for ongoing research.
  • The first follow-up recorded a response rate of 82.40% (918 patients).
  • No significant differences were found between followed-up and non-followed-up patients, apart from younger age in the followed-up group.

Conclusions:

  • The CKC cohort provides a valuable resource for studying keratoconus in the Chinese population.
  • This study is the first to explore gene-environment interactions in keratoconus progression.
  • The established cohort and initial follow-up data support future research into KC prevention.