Relationships between sarcopenia, depressive symptoms, and the risk of cardiovascular disease in Chinese population

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Tongneng Xue1, Yang Gu1, Hai Xu1

  • 1Department of Cardiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, Jiangsu Province, China.

The Journal of Nutrition, Health & Aging
|May 4, 2024
PubMed

Insights

Sarcopenia and depressive symptoms together significantly increase cardiovascular disease (CVD) risk. Early identification and intervention for both conditions are crucial for all age groups.

Area of Science:

  • Gerontology
  • Cardiology
  • Psychiatry

Background:

  • Sarcopenia and depressive symptoms are independently linked to higher cardiovascular disease (CVD) risk.
  • The combined impact of sarcopenia and depressive symptoms on CVD risk requires further investigation.

Purpose of the Study:

  • To evaluate the synergistic effect of sarcopenia and depressive symptoms on the risk of developing new-onset cardiovascular disease (CVD).
  • To analyze the combined impact on stroke and cardiac events.

Main Methods:

  • Utilized data from 11,011 participants in the China Health and Retirement Longitudinal Study (2011-2020).
  • Employed multivariate Cox proportional hazards regression models to assess associations.
  • Examined the interactions between sarcopenia and depressive symptoms concerning CVD incidence.

Main Results:

  • Over a 7-year follow-up, 2,388 participants developed CVD, including 812 strokes and 1,831 cardiac events.
  • Significant additive and multiplicative interactions were observed between sarcopenia and depressive symptoms for CVD, stroke, and cardiac events.
  • Individuals with 'depressive sarcopenia' exhibited the highest risk: HR 1.43 (CVD), 1.45 (stroke), 1.50 (cardiac events).

Conclusions:

  • Sarcopenia and depressive symptoms exert a combined effect on the risk of CVD, stroke, and cardiac events.
  • Highlights the importance of early identification and intervention for sarcopenia and depressive symptoms in both older and younger populations.
Abstract

Keywords:
CHARLSCVDDepressive symptomsSarcopenia

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