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Transient albuminuria in the setting of short-term severe hyperglycemia in type 1 diabetes

Jia Xin Huang1, Timothy P Copeland2, Casey E Pitts2

  • 1Department of Pediatrics, University of California San Francisco, United States of America.

Journal of Diabetes and Its Complications
|May 4, 2024
PubMed

Insights

Short-term high blood sugar in children with type 1 diabetes (T1D) can cause temporary albuminuria. This finding suggests a potential risk for diabetic kidney disease, warranting further research.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Nephrology

Background:

  • Type 1 diabetes (T1D) is a chronic condition affecting children.
  • Diabetic kidney disease is a serious complication of diabetes.
  • The link between hyperglycemia and early kidney markers in pediatric T1D needs clarification.

Purpose of the Study:

  • To investigate the association between short-term hyperglycemia and transient albuminuria in children with T1D.
  • To assess the prevalence of albuminuria during different T1D-related events (new-onset, diabetic ketoacidosis, routine screening).

Main Methods:

  • Retrospective cohort study of 1817 children with T1D.
  • Analysis of albuminuria prevalence in relation to glycemic control and T1D status (new-onset, DKA, routine screening).

Main Results:

  • Transient albuminuria was observed in 11% of children during new-onset T1D without DKA.
  • Albuminuria occurred in 12% of children during or after DKA.
  • A lower prevalence of 6% was noted during routine screening.

Conclusions:

  • Short-term hyperglycemia is linked to transient albuminuria in pediatric T1D.
  • These findings highlight potential early kidney damage indicators.
  • Further investigation is crucial to understand long-term diabetic kidney disease risk.

Keywords:
Diabetic ketoacidosisType 1 diabetesUrine albumin-to-creatinine ratio

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