Related Experiment Video
Updated: Jun 27, 2025
04:30
Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
3.4K
Atrioventricular conduction disorders in aortic valve infective endocarditis
Mary Philip1, Jérôme Hourdain1, Noémie Resseguier2
1Cardiology Department, La Timone Hospital, AP-HM, 264, rue Saint-Pierre, 13005 Marseille, France.
Archives of Cardiovascular Diseases
|May 4, 2024
Summary
High-degree atrioventricular block in aortic valve infective endocarditis is linked to inflammation and periannular complications. This condition increases in-hospital mortality risk, necessitating careful patient assessment.
Area of Science:
- Cardiology
- Infectious Diseases
- Electrophysiology
Background:
- Aortic valve infective endocarditis (AVIE) can lead to high-degree atrioventricular block (HAVB) in 10-20% of cases.
- Understanding the factors and outcomes associated with HAVB in AVIE is crucial for patient management.
Purpose of the Study:
- To investigate the occurrence, contributing factors, prognosis, and long-term evolution of HAVB in patients with AVIE.
- To identify predictors of HAVB and its impact on in-hospital mortality.
Main Methods:
- A cohort of 205 patients with AVIE was studied between January 2018 and March 2021.
- Comprehensive data including clinical, electrocardiographic, biological, microbiological, and imaging findings were collected.
- A 1-year follow-up was conducted to assess patient outcomes.
Main Results:
- HAVB occurred in 11% of patients with AVIE.
- Predictors of HAVB included first-degree heart block on admission, periannular complications on echocardiography, and severe inflammatory markers (e.g., C-reactive protein).
- In-hospital mortality was higher in patients with HAVB (12.7%). Among those with pacemakers, only 25% remained pacemaker-dependent at 1 year.
Conclusions:
- HAVB in AVIE is associated with significant inflammation and periannular complications.
- HAVB serves as an indicator of infectious severity and is linked to increased in-hospital mortality.
- Systematic assessment for HAVB risk factors can guide intensive care unit monitoring and timely intervention, potentially including temporary pacemaker implantation.
Related Concept Videos
01:28Mechanism of Cardiac Arrhythmias
917
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
917
01:16Heart Valves
4.6K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
4.6K
01:28Disturbances in Heart Rhythm
945
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
945
01:25Cardiovascular System Abnormal Findings II: Auscultation
139
Auscultation, an essential part of a heart examination, is done using a stethoscope. It provides crucial information about heart function and possible heart problems. Due to heart problems, abnormal sounds can be heard during systole or diastole. These sounds include S3 and S4 gallops, opening snaps, systolic clicks, and murmurs.
Abnormal Heart Sounds
Gallops:
Abnormal Heart Sounds
Gallops:
139
01:20Conduction System of the Heart
995
The cardiac conduction system produces and transmits electrical impulses that prompt myocardial contraction, ensuring efficient heart function. This intricate system ensures that the heart beats in a coordinated and efficient manner, beginning with the atria and then the ventricles. The conduction system optimizes cardiac output by maintaining this precise sequence, which is crucial for adequate blood circulation.
This system relies on the unique properties of nodal and Purkinje cells:...
This system relies on the unique properties of nodal and Purkinje cells:...
995
01:16ECG Interpretation of Arrhythmias I: Sinus Arrhythmias
213
Arrhythmias are disturbances in the heart's rhythm that lead to abnormal heartbeats. These irregularities can originate from different parts of the heart and are classified based on their origin and nature.
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
213