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Maria Færch Andersen1, Line Rode2, Iben Louise Riishede Christiansen3

  • 1Det Sundhedsvidenskabelige Fakultet, Københavns Universitet.

Ugeskrift for Laeger
|May 5, 2024
PubMed
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Low-dose aspirin (LDA) is recommended for high-risk pregnancies to prevent pre-eclampsia. While LDA may slightly increase bleeding risk, overall safety data during pregnancy is promising.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Pharmacology

Background:

  • Pre-eclampsia impacts 3-4% of pregnancies, causing significant maternal and infant mortality.
  • Prophylactic low-dose aspirin (LDA) is recommended for high-risk pregnancies in Denmark.
  • New screening algorithms may extend LDA recommendations to 10% of pregnant women.

Purpose of the Study:

  • To review the safety and efficacy of low-dose aspirin (LDA) for pre-eclampsia prevention.
  • To evaluate the potential risks and benefits of increased LDA use in pregnancy.

Main Methods:

  • Literature review of existing studies on LDA use in pregnancy.
  • Analysis of data on pre-eclampsia incidence and risk factors.
  • Assessment of bleeding risks associated with LDA.

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Main Results:

  • LDA is a recommended prophylactic treatment for high-risk pregnancies.
  • Potential for a slight increase in minor bleeding disturbances with LDA use.
  • Extensive promising data supports the overall safety of LDA during pregnancy.

Conclusions:

  • LDA remains a valuable tool in managing high-risk pregnancies and preventing pre-eclampsia.
  • The benefits of LDA in preventing severe maternal and infant outcomes outweigh the minor bleeding risks.
  • Continued research and updated screening algorithms support wider LDA application.