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The long non-coding RNAs (lncRNA) in the pathogenesis of gastric cancer cells: molecular mechanisms and involvement
Raed Obaid Saleh1, Sulieman Ibraheem Shelash Al-Hawary2, Ahmad Hammoud3,4
1Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Iraq.
Molecular Biology Reports
|May 5, 2024
Summary
Long non-coding RNAs (lncRNAs) play crucial roles in gastric cancer (GC) development. This review highlights key lncRNAs like ADAMTS9-AS2 and UCA1, impacting GC cell apoptosis, migration, and invasion.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Gastric cancer (GC) arises from genetic vulnerability, H. pylori infection, and environmental factors.
- Genetic and epigenetic alterations dysregulate cell cycle and apoptosis, leading to GC.
- Advancements in RNA sequencing enable the study of long non-coding RNAs (lncRNAs).
Purpose of the Study:
- To review the multifaceted roles of lncRNAs in gastric cancer development.
- To explore specific GC-associated lncRNAs and their mechanisms of action.
- To summarize recent findings on lncRNAs influencing GC cell apoptosis, migration, invasion, and drug resistance.
Main Methods:
- Literature review of recent studies on lncRNAs and gastric cancer.
- Focus on computational biology and RNA-seq based research.
- Analysis of lncRNA interactions with protein, RNA, and DNA molecules.
Main Results:
- lncRNAs are implicated in various stages of GC development.
- Specific lncRNAs, including ADAMTS9-AS2, UCA1, XBP-1, and LINC00152, are associated with GC.
- These lncRNAs can modulate GC cell apoptosis, migration, and invasion within the tumor microenvironment.
Conclusions:
- lncRNAs are significant regulators in gastric cancer pathogenesis.
- Targeting specific lncRNAs presents potential therapeutic strategies for GC.
- Further research into lncRNA functions is crucial for understanding and treating GC.
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