Clinical correlation between disease progression and central vein sign in pediatric onset multiple sclerosis: A

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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

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Shay Menascu1, Simona Halusková2, Amir Pollak1

  • 1Multiple Sclerosis Center, Sheba Medical Center, Ramat-Gan, Israel; Faculty of Medical and Health Sciences, Tel-Aviv University, Israel.

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
|May 5, 2024
PubMed

Insights

The central vein sign (CVS) indicates faster disease progression in pediatric-onset multiple sclerosis (POMS). CVS-positive POMS patients show higher disability scores and relapse rates, highlighting CVS

Area of Science:

  • Neurology
  • Radiology
  • Pediatrics

Background:

  • The central vein sign (CVS) is a proposed MRI biomarker for diagnosing pediatric-onset multiple sclerosis (POMS).
  • The association between CVS and POMS progression remains under-explored.

Purpose of the Study:

  • To investigate the presence of CVS in POMS patients.
  • To determine the correlation between CVS and POMS disease progression.

Main Methods:

  • 156 POMS patients from two centers were followed for five years.
  • Disease progression was assessed using the Expanded Disability Status Scale (EDSS) and Annual Relapse Rate (ARR).
  • CVS-positive status was defined by at least 40% of brain MRI lesions exhibiting CVS.

Main Results:

  • CVS-positive POMS patients (38.5%) showed significantly higher EDSS scores at 3 and 5-year follow-ups compared to CVS-negative patients.
  • CVS-positive POMS patients exhibited a significantly higher ARR.
  • These findings were consistent across subgroups of patients with or without Disease Modifying Treatments (DMT).

Conclusions:

  • CVS-positive POMS is associated with more rapid disability progression.
  • CVS may play a significant role in the pathogenesis of POMS.
Abstract

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