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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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  11. Layer-by-layer Coated Probiotics With Chitosan And Liposomes Exhibit Enhanced Therapeutic Effects For Dss-induced Colitis In Mice

Layer-by-layer coated probiotics with chitosan and liposomes exhibit enhanced therapeutic effects for DSS-induced colitis in mice

Mengzhen Han1, Ning Shen1, Weiteng Tan1

  • 1College of Food Science and Engineering, Northwest A&F University, 712100 Yangling, Shaanxi, China.

International Journal of Biological Macromolecules
|May 5, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Coated probiotics with curcumin liposomes improve survival and gut barrier repair for gastrointestinal diseases. This novel approach enhances probiotic efficacy in treating conditions like colitis.

Area of Science:

  • Gastroenterology
  • Microbiology
  • Biomaterials Science

Background:

  • Oral probiotics face challenges in the gastrointestinal tract, including low pH, bile salts, and reactive oxygen species (ROS), reducing survival and efficacy.
  • Damage to the protective mucus layer further compromises probiotic function in treating gastrointestinal disorders.

Purpose of the Study:

  • To develop a novel layer-by-layer coating for probiotics using curcumin-loaded liposomes and polymers.
  • To enhance probiotic survival, adhesion, and therapeutic efficacy in gastrointestinal diseases, specifically colitis.

Main Methods:

  • Development of layer-by-layer coated probiotics incorporating curcumin-loaded liposomes and polymers.
  • Evaluation of coated probiotic survival and adhesion in a DSS-induced colitis mouse model.
Keywords:
ChitosanCurcuminInflammatory bowel diseaseLiposome nanocoating

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  • Assessment of the therapeutic effects on gut barrier repair, microbial homeostasis, and inflammation.

    • Main Results:

    • Coated probiotics demonstrated significantly improved survival rates within the gastrointestinal tract.
    • Enhanced adhesion of coated probiotics to the intestinal mucosa was observed.
    • Multi-layered coated probiotics effectively alleviated colitis by repairing the gut barrier, restoring microbial balance, and reducing inflammation.

    Conclusions:

    • Layer-by-layer coated probiotics with curcumin liposomes represent a promising strategy to overcome challenges in oral probiotic delivery.
    • This innovative approach shows significant potential for the effective treatment of gastrointestinal diseases, including inflammatory conditions like colitis.
    Oral probiotics delivery