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Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

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Predicting Spontaneous Preterm Birth Using the Immunome.

Dorien Feyaerts¹, Ivana Marić², Petra C Arck³

¹Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA 94305, USA.

Clinics in Perinatology

|May 5, 2024

Summary

This summary is machine-generated.

Maternal immune dynamics in circulation offer insights into pregnancy progression and can predict spontaneous preterm birth (sPTB). Understanding these immune changes may lead to early risk assessment and new biomarkers for sPTB.

Keywords:

Maternal blood Maternal immune system Multiomics modeling Single-cell cytometry Spontaneous preterm birth Spontaneous preterm labor Whole blood transcriptome

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Published on: June 24, 2020

Area of Science:

Immunology
Reproductive Biology
Computational Biology

Background:

Pregnancy involves complex immune regulation, with peripheral circulation reflecting these changes.
Local immune responses at the maternal-fetal interface influence systemic immunity.
Spontaneous preterm birth (sPTB) is a critical obstetric complication with a need for early prediction.

Purpose of the Study:

To explore the potential of maternal immune dynamics as a predictive tool for spontaneous preterm birth (sPTB).
To investigate the role of cross-tissue immune interactions in pregnancy.
To identify novel biomarkers for early risk assessment of sPTB.

Main Methods:

Utilizing systems immunology approaches to analyze immune cell status.
Examining interactions between local reproductive tissues and peripheral circulation.
Integrating multiple biological data modalities for comprehensive analysis.

Main Results:

Maternal peripheral circulation harbors immune signatures indicative of pregnancy status.
Immune dynamics are tightly regulated throughout gestation.
These immune patterns are linked to the risk of spontaneous preterm birth.

Conclusions:

The cellular immune status during pregnancy can serve as an early warning system for sPTB.
Systems immunology and multi-modal data integration can enhance understanding of preterm birth.
This research promises to identify clinically actionable biomarkers for sPTB prediction.