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[Translated article] Syringes for intraocular administration: A systematic review.

Ángela Pascual Carrasco1, Isabel Espadas García1, Ana Ramírez López1

  • 1Servicio de Farmacia, Hospital General Universitario Doctor Balmis, Alicante, Spain.

Farmacia Hospitalaria : Organo Oficial De Expresion Cientifica De La Sociedad Espanola De Farmacia Hospitalaria
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Summary

The off-label use of non-approved syringes for intravitreal injections can lead to silicone oil in the eye. This review highlights the need for silicone-free, intraocular-specific syringes to ensure patient safety and regulatory compliance.

Keywords:
Aceite de siliconaAgujaIntraocular injectionIntravitreal injectionInyección intraocularInyección intravítreaJeringaNeedleOff-label useSilicone oilSyringeUso Off-Label

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Area of Science:

  • Ophthalmology
  • Medical Device Engineering
  • Materials Science

Background:

  • Off-label use of non-approved syringes for intravitreal drug administration is prevalent.
  • Detection of silicone oil droplets in the vitreous of patients has been reported.
  • Lack of regulatory-approved intraocular syringes in the Spanish market necessitates this review.

Approach:

  • A systematic review was conducted following PRISMA 2020 guidelines.
  • PubMed database was searched for articles published between January 2006 and December 2023.
  • Studies focused on silicone oil release in intravitreal injections and potential consequences were analyzed.

Key Points:

  • 45 articles were included in the systematic review.
  • Findings were categorized into adverse reactions, administration technique, silicone release, and device characteristics.
  • Two silicone-free syringes, Zero Residual™ 0.2 ml SiO-free and VitreJect® Ophthalmic, are anticipated for the Spanish market in early 2024.

Conclusions:

  • Silicone-containing syringes for intravitreal use pose a risk of adverse patient reactions.
  • The development and availability of silicone-free syringes specifically for intraocular use are crucial.
  • Ensuring safety and legal compliance in intraocular syringe and needle use is paramount for patient ocular health.