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[Translated article] Syringes for intraocular administration: A systematic review
Ángela Pascual Carrasco1, Isabel Espadas García1, Ana Ramírez López1
1Servicio de Farmacia, Hospital General Universitario Doctor Balmis, Alicante, Spain.
Summary
The off-label use of non-approved syringes for intravitreal injections can lead to silicone oil in the eye. This review highlights the need for silicone-free, intraocular-specific syringes to ensure patient safety and regulatory compliance.
Area of Science:
- Ophthalmology
- Medical Device Engineering
- Materials Science
Background:
- Off-label use of non-approved syringes for intravitreal drug administration is prevalent.
- Detection of silicone oil droplets in the vitreous of patients has been reported.
- Lack of regulatory-approved intraocular syringes in the Spanish market necessitates this review.
Approach:
- A systematic review was conducted following PRISMA 2020 guidelines.
- PubMed database was searched for articles published between January 2006 and December 2023.
- Studies focused on silicone oil release in intravitreal injections and potential consequences were analyzed.
Key Points:
- 45 articles were included in the systematic review.
- Findings were categorized into adverse reactions, administration technique, silicone release, and device characteristics.
- Two silicone-free syringes, Zero Residual™ 0.2 ml SiO-free and VitreJect® Ophthalmic, are anticipated for the Spanish market in early 2024.
Conclusions:
- Silicone-containing syringes for intravitreal use pose a risk of adverse patient reactions.
- The development and availability of silicone-free syringes specifically for intraocular use are crucial.
- Ensuring safety and legal compliance in intraocular syringe and needle use is paramount for patient ocular health.
