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[Progressive necrotizing xanthogranuloma in both eyes: a case report]
1Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226000, China.
Summary
Progressive necrotizing xanthogranuloma, a rare condition, can manifest with skin lesions and eye inflammation. This case highlights its association with mantle cell lymphoma and potential treatment response.
Area of Science:
- Dermatology
- Ophthalmology
- Hematology
Background:
- Progressive necrotizing xanthogranuloma is a rare disorder characterized by xanthoma and granuloma formation.
- Mantle cell lymphoma is a type of non-Hodgkin lymphoma that can affect various organs.
Observation:
- A 55-year-old male presented with bilateral difficulty in eye opening, eyelid plaques/nodules, and ocular inflammation (keratitis, iridocyclitis).
- Skin lesions on the chest showed xanthomatous granulomas with necrosis.
- Bone marrow biopsy confirmed mantle cell lymphoma.
Findings:
- The patient was diagnosed with progressive necrotizing xanthogranuloma associated with mantle cell lymphoma.
- Histopathology confirmed dermal xanthomatous granulomas with necrosis and mantle cell lymphoma in the bone marrow.
Implications:
- This case underscores the importance of considering systemic associations, like lymphoma, in patients with xanthogranulomatous diseases.
- Combined chemotherapy (bendamustine and rituximab) showed partial efficacy in alleviating ocular symptoms, suggesting a potential therapeutic approach.
