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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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China Initiative for Multi-Domain Intervention (CHINA-IN-MUDI) to Prevent Cognitive Decline: Study Design and

S-Y Li1, X-Y Xie, D Liu

  • 1Yan Zeng, Brain Science and Advanced Technology Institute, School of Medicine, Wuhan University of Science and Technology, West Huangjiahu Road, Hongshan District, Wuhan 430065, China. Email: zengyan68@wust.edu.cn; Jin-Tai Yu, Department of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Huashan Hospital, Shanghai Medical College, Fudan University, 12th Wulumuqi Zhong Road, Shanghai 200040, China. Email: jintai_yu@fudan.edu.cn; Wei Tan, Geriatric Hospital Affiliated to Wuhan University of Science and Technology, West Huangjiahu Road, Hongshan District, Wuhan 430065, China.

The Journal of Prevention of Alzheimer'S Disease
|May 6, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces CHINA-IN-MUDI, a lifestyle intervention to prevent cognitive decline in China. It aims to provide evidence for public health strategies against Alzheimer's disease (AD).

Keywords:
Alzheimer’s diseasemulti-domain behavioral interventionmulticenterpreclinical stagesrandomized controlled clinical trialthe Chinese Healthy Aging and Dementia Study

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Area of Science:

  • Gerontology and Public Health
  • Neuroscience and Clinical Trials

Background:

  • Alzheimer's disease (AD) poses a growing global health challenge, with projections indicating a significant increase in cases by 2050.
  • Previous multi-domain lifestyle interventions in Europe show promise for dementia prevention, but direct application in China is limited due to demographic and cultural differences.
  • Existing Chinese trials lack national representativeness, highlighting the need for diverse cohorts to accurately assess early intervention effectiveness.

Purpose of the Study:

  • To develop and evaluate a culturally adapted, multi-domain lifestyle intervention (CHINA-IN-MUDI) for cognitive decline prevention in a representative Chinese population.
  • To assess the feasibility and effectiveness of a Chinese-style intervention, building upon the FINGER study design.
  • To explore implementation strategies and evaluate early multi-domain interventions comprehensively in diverse Chinese settings.

Main Methods:

  • The China Initiative for Multi-Domain Intervention (CHINA-IN-MUDI) is a 2-year, multicenter, open-label, cluster-randomised controlled trial.
  • Participants (aged 60-80) were recruited from the China Healthy Aging and Dementia Study cohort, ensuring national representativeness.
  • Intervention programs were standardized to align with Chinese cultural and socioeconomic contexts, incorporating genomic/proteomic analyses and an e-health application for adherence.

Main Results:

  • Screening began in July 2022, with 1,965 participants randomized (772 intervention, 1,193 control).
  • Baseline characteristics were similar between groups, revealing prevalent lifestyle and vascular risk factors.
  • The trial is ongoing, with completion expected in 2025.

Conclusions:

  • The CHINA-IN-MUDI project will evaluate the effectiveness and safety of multi-domain interventions for Alzheimer's disease (AD) risk reduction.
  • Findings will inform public health decision-making in China regarding dementia prevention strategies.
  • This study provides a basis for implementing and adapting lifestyle interventions for cognitive health in diverse populations.