Diabetes complications and cognitive function in young adults with youth-onset type 1 or type 2 diabetes: the SEARCH for Diabetes in Youth Study
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View abstract on PubMed
Summary
This summary is machine-generated.Cognitive deficits in youth-onset diabetes are linked to complications. Peripheral neuropathy is common in both type 1 and type 2 diabetes, while hypoglycemia affects T1D and high blood pressure affects T2D, impacting cognition.
Area Of Science
- Endocrinology
- Neuroscience
- Public Health
Background
- Diabetes complications, including retinopathy, microalbuminuria, and peripheral neuropathy (PN), are associated with cognitive deficits.
- The co-occurrence of multiple diabetes complications and cognitive dysfunction in youth-onset type 1 (T1D) and type 2 diabetes (T2D) requires further investigation.
Purpose Of The Study
- To examine the clustering of diabetes complications and associated clinical factors with cognitive performance in young adults with youth-onset T1D or T2D.
- To identify shared and unique factors contributing to cognitive dysfunction in these populations.
Main Methods
- Utilized data from the prospective longitudinal SEARCH for Diabetes in Youth study cohort.
- Assessed cognition using the NIH Toolbox Cognition Battery, focusing on composite fluid cognition scores.
- Employed cluster analysis to identify patterns of complications and clinical factors (lipids, SBP, HbA1c, PN) in T1D (n=646) and T2D (n=165) cohorts.
Main Results
- Significant differences in average fluid cognition scores were observed across clusters for both T1D and T2D groups (p<0.001).
- In T1D, lower cognition was associated with higher frequency of hypoglycemia and higher prevalence of PN.
- In T2D, lower cognition was linked to higher systolic blood pressure (SBP) and higher prevalence of PN.
Conclusions
- Peripheral neuropathy (PN) is a shared factor associated with cognitive impairment in both T1D and T2D.
- Hypoglycemia in T1D and elevated SBP in T2D represent unique factors that may contribute to cognitive deficits.
- Targeting these identified factors could offer strategies to mitigate cognitive issues in young individuals with youth-onset diabetes.
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