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Identification of glutamine metabolism-related gene signature to predict colorectal cancer prognosis

  • 0Department of Gastroenterology, digestive disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang China.
Journal of Cancer +

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May 6, 2024

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May 6, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This study identifies 15 glutamine metabolism genes that predict colorectal cancer (CRC) prognosis. A new gene signature accurately forecasts patient survival, offering potential metabolic targets for CRC treatment.

Area Of Science

  • Oncology
  • Metabolic pathways
  • Genomics

Background

  • Colorectal cancer (CRC) is a significant global health burden with poor prognosis.
  • Genes involved in glutamine metabolism are implicated in CRC development.
  • The prognostic value of these metabolic genes in CRC remains unexplored.

Purpose Of The Study

  • To identify glutamine metabolism-related genes associated with colorectal cancer prognosis.
  • To develop and validate a prognostic gene signature for CRC.
  • To explore the relationship between the gene signature, clinical factors, and immune infiltration.

Main Methods

  • Utilized TCGA data and MSigDB gene sets to identify 15 prognostic glutamine metabolism genes via COX regression.
  • Developed a risk score model, validated with Kaplan-Meier and ROC analyses.
  • Assessed clinical correlations, immune cell infiltration (ssGSEA), and constructed nomograms; validated core gene expression via IHC.

Main Results

  • Identified 15 key glutamine metabolism genes (e.g., PHGDH, GLYATL1) linked to CRC prognosis.
  • The developed risk score model effectively stratified patients into high- and low-risk groups with distinct overall survival (OS) outcomes.
  • Risk score positively correlated with clinical and TNM stages; low-risk group showed Th2 cell predominance; nomogram demonstrated strong discriminatory power.

Conclusions

  • A novel gene signature based on glutamine metabolism genes reliably predicts CRC patient prognosis.
  • This signature offers potential as a therapeutic metabolic target for colorectal cancer.
  • The findings provide new insights into the role of glutamine metabolism in CRC progression and immunity.

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