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Related Experiment Videos

Postnatal growth of the mouse bladder.

S P Jost1

  • 1Department of Anatomy, University of Manchester, England.

Journal of Anatomy
|December 1, 1985
PubMed
Summary

Mouse bladders grow significantly after birth, but at a slower rate than overall body weight. This suggests the mouse bladder is relatively mature at birth, with most growth occurring in non-urothelial tissues.

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Virchows Archiv. B, Cell pathology including molecular pathology·1989

Area of Science:

  • Developmental biology
  • Urology
  • Mouse models

Background:

  • Understanding organ development is crucial in developmental biology.
  • The mouse bladder undergoes significant postnatal changes.
  • Previous research has not fully characterized bladder growth relative to body weight in mice.

Purpose of the Study:

  • To quantify the postnatal growth of the mouse bladder.
  • To compare bladder growth with overall body weight gain in mice.
  • To assess the developmental maturity of the mouse bladder at birth.

Main Methods:

  • Measurements of bladder surface area and wet weight in mice from birth to ten weeks.
  • Calculation of the ratio of bladder weight to total body weight.
  • Age-based analysis of growth patterns.

Main Results:

  • Bladder size (surface area) increased 2.5-fold and wet weight increased 4-fold by ten weeks.
  • Body weight increased 10-15 fold during the same period.
  • The bladder weight to body weight ratio decreased steadily, stabilizing by five weeks.

Conclusions:

  • The mouse bladder exhibits substantial postnatal growth, primarily in non-urothelial components.
  • The relative growth rate of the bladder is slower than that of the body.
  • These findings indicate a significant degree of bladder maturity at the time of birth in mice.

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