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Updated: Jun 27, 2025

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Published on: December 6, 2016
The causal relationship between obesity, obstructive sleep apnea and atrial fibrillation: a study based on mediated
Tianyu Li1, Li Rong1, Yanlin Gao1
1Department of Cardiology, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, China.
Background:
Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with obesity and obstructive sleep apnea syndrome (OSA). Obesity and OSA may increase the risk of AF by affecting cardiovascular health.
Methods:
The study used the Mendelian randomization (MR) approach, combined with two-sample and multivariable analyses, to assess the relationships between obesity, OSA, and AF. The study utilized GWAS data and applied various statistical methods for the analysis.
Results:
The study found that obesity increased the risk of OSA, which in turn significantly increased the risk of AF. Through mediating MR analysis, it was found that OSA played a certain role in the causal relationship between obesity and AF, with about 6.4% of the risk of AF being mediated by OSA.
Conclusion:
This study highlights the relationships among obesity, OSA, and AF, providing useful guidance for future clinical researches.
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