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Hospitalized patients' attitudes towards participating in a randomized control trial in case of a cardiac arrest
Malin Albert1, Marie Thonander2,3, Sune Forsberg1,4
1Department of Clinical Science and Education, Södersjukhuset, Centre for Resuscitation Science, Karolinska Institutet, Sweden.
Insights
Most hospitalized patients are willing to join cardiac arrest clinical trials. The primary motivation for participation in the Vasopressin and Steroids in addition to Adrenaline in cardiac arrest (VAST-A) trial is to contribute to medical research.
Area of Science:
- Clinical Research
- Cardiology
- Emergency Medicine
Background:
- No prior studies have assessed patient attitudes toward participating in cardiac arrest clinical trials.
- This study aimed to evaluate patient willingness and motives for the Vasopressin and Steroids in addition to Adrenaline in cardiac arrest (VAST-A) trial.
Purpose of the Study:
- To assess patient willingness to be included in an in-hospital cardiac arrest (IHCA) clinical trial.
- To understand patient motivations for approving or declining trial participation.
Main Methods:
- Hospitalized patients provided informed consent for potential inclusion in the VAST-A trial during their hospital stay.
- Patients were surveyed on their willingness to participate, reasons for consent decisions, and baseline characteristics.
Main Results:
- Out of 1,064 patients surveyed, 902 (84.8%) agreed to participate in the VAST-A trial.
- For a subgroup of 411 patients, the main reason for approval was to contribute to research (83.9%).
- Concerns about drug treatment testing were the primary reason for declining participation (30%).
Conclusions:
- The majority of hospitalized patients are willing to provide informed consent for inclusion in cardiac arrest drug trials.
- Patient willingness to participate in clinical trials is largely driven by a desire to advance medical research.
Background:
No previous study has evaluated patients attitudes towards inclusion in an ongoing cardiac arrest clinical trial. The aim of this study was to assess patientś willingness and motives to participate in the ongoing randomized controlled drug trial "Vasopressin and Steroids in addition to Adrenaline in cardiac arrest" (VAST-A trial) in case of an in-hospital cardiac arrest (IHCA).
Objectives:
Hospitalized patients, men ≥ 18 and women ≥ 50 years, were asked for informed consent for inclusion in the VAST-A trial in case of an IHCA, the reason for approving or declining inclusion in the trial and baseline characteristics.
Methods:
Patients admitted to hospital were asked to give informed consent of inclusion in VAST-A in case of an IHCA during their hospital stay. Patients were also asked why they approved or declined inclusion as well as baseline characteristics questions.
Results:
1,064 patients were asked about willingness to participate in the VAST-A trial, of these 902 (84.8%) patients approved inclusion. A subgroup of 411 patients were, except willingness, also asked about motives to participate or not and basic characteristics. The main reason for approving inclusion was to contribute to research (n = 328, 83.9%). The main reason for declining inclusion was concerns regarding testing the drug treatment (n = 6, 30%).
Conclusion:
Among hospitalized patients the vast majority gave informed consent to inclusion in an ongoing randomized cardiac arrest drug trial. The main reason for approving inclusion was to contribute to research.
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