Establishment of Prognosis Nomogram for Primary Splenic Diffuse Large B Cell Lymphoma: A Study Based on SEER Database

Area of Science:

• Hematology
• Oncology
• Medical Statistics

Background:

• Primary spleen diffuse large B-cell lymphoma (DLBCL) is the most common splenic tumor.
• Prognostic prediction for primary spleen DLBCL has been limited.
• Need for improved tools to guide individualized treatment strategies.

Purpose of the Study:

• To establish a nomogram prediction model for overall survival in primary spleen DLBCL.
• To evaluate the predictive accuracy and clinical utility of the developed nomogram.

Main Methods:

• Retrospective analysis of 347 patients with primary splenic DLBCL from the SEER database.
• Cox regression analysis to identify independent risk factors (age, Ann Arbor Stage, splenectomy, chemotherapy).
• Nomogram construction and validation using C-Index, ROCAUC, calibration plots, and decision curve analysis.

Main Results:

• The nomogram demonstrated good predictive ability with C-Index values of 0.719 (training) and 0.711 (validation).
• Calibration plots indicated good agreement between predicted and actual survival.
• Decision curve analysis showed the nomogram's superiority over Ann Arbor Stage for prognosis prediction.

Conclusions:

• A validated nomogram prediction model for primary spleen DLBCL has been established.
• The nomogram possesses good predictive and generalization capabilities.
• This tool can assist clinicians in developing individualized treatment plans for patients with primary spleen DLBCL.