Related Experiment Video

Updated: Jun 27, 2025

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics
07:42

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Published on: February 19, 2017

8.8K

Rod-Shaped Hemoglobin Crystals: Clues to the Diagnosis of Hemoglobin C Disease

Ke Xu1,2, Jiwei Zhao3, Boubacar Sidiki Ibrahim Dramé2

  • 1Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, 310014 China.

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
|May 6, 2024
PubMed

Insights

Hemoglobin C (HbC) disease diagnosis can be challenging. Careful examination of peripheral blood smears for characteristic HbC crystals is crucial, even with normal routine blood tests.

Area of Science:

  • Hematology
  • Medical Diagnostics

Background:

  • Hemoglobin C (HbC) disease is a hemoglobinopathy.
  • Diagnosis often relies on identifying HbC crystals in peripheral blood smears.

Purpose of the Study:

  • To highlight the diagnostic utility of peripheral blood film morphology in detecting HbC disease.
  • To emphasize the importance of careful blood smear review, especially in cases with normal routine blood tests.

Main Methods:

  • Case report focusing on blood film morphology.
  • Review of peripheral blood smear for characteristic rod-shaped HbC crystals.

Main Results:

  • Typical rod-shaped HbC crystals were observed in the peripheral blood smear.
  • These crystals served as a key diagnostic clue for HbC disease.

Conclusions:

  • Peripheral blood film morphology is a valuable tool for diagnosing HbC disease.
  • Blood smear examination can detect HbC disease even when routine blood tests are normal and do not warrant re-examination.

Keywords:
CluesHemoglobin C diseaseRod-shaped hemoglobin crystals

More Related Videos

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques08:58

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques

Published on: July 5, 2018

12.6K
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

30.6K

Related Concept Videos

Karyotyping01:17

Karyotyping

Overview
60.1K
X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...
3.8K
Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
79.5K
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.4K