Nondestructive Measurement Technique for Substandard Amoxicillin Based on Thermal Approach

Area of Science:

• Analytical Chemistry
• Pharmaceutical Analysis
• Non-destructive Testing

Background:

• Quality control of amoxicillin is crucial for patient safety, requiring accurate determination of active ingredient content.
• Traditional methods for amoxicillin analysis are time-consuming, require skilled personnel, and often need specific reagents.

Purpose of the Study:

• To introduce a novel, nondestructive thermal measurement technique for determining substandard amoxicillin.
• To develop a rapid, low-cost, and accurate alternative for quantifying amoxicillin content without sample damage.

Main Methods:

• A thermal approach was employed for nondestructive measurement of amoxicillin content.
• Method validation included assessing the coefficient of determination (R²), percent recoveries, limit of detection (LOD), and limit of quantitation (LOQ).
• Experiments utilized amoxicillin samples with concentrations below standard quality in aqueous solutions.

Main Results:

• The method achieved a coefficient of determination (R²) exceeding 0.99 and percent recoveries between 98.70-103.40%.
• LOD and LOQ were determined to be 28.11 mg/L and 85.17 mg/L, respectively.
• Measurements were completed in under 10 minutes, demonstrating high analytical efficiency.

Conclusions:

• The proposed thermal technique effectively quantifies amoxicillin content in aqueous solutions, identifying substandard samples.
• Independent validation at international institutions confirms the technique's effectiveness and robustness.
• This study validates the feasibility of using a thermal approach for rapid, nondestructive quality control of amoxicillin.