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Improving  in vivo assays in snake venom and antivenom research: A community discussion

  • 0Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, England, L3 5RF, UK.
F1000research +

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May 6, 2024

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May 6, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Researchers discussed improving snake venom lethality mouse assays for better antivenom research. The goal is to refine animal testing while advancing preclinical snakebite envenoming therapies.

Area Of Science

  • * Zoology and Toxicology
  • * Biomedical Research

Background

  • * Snakebite envenoming is a significant global health issue.
  • * Current preclinical assessment of antivenom efficacy relies on venom lethality mouse assays.
  • * These assays are used worldwide to evaluate therapeutic interventions.

Purpose Of The Study

  • * To discuss and identify improvements for *in vivo* snake venom research.
  • * To explore refinements in venom lethality mouse assays.
  • * To reduce and refine animal testing in preclinical snakebite research.

Main Methods

  • * A virtual community discussion meeting was held.
  • * Researchers globally participated in the discussion.
  • * Key perspectives on existing assays were presented and debated.

Main Results

  • * Strengths and weaknesses of current venom lethality mouse assays were highlighted.
  • * Discussions focused on potential improvements to the assays.
  • * The need for refined methods supporting antivenom and drug discovery was emphasized.

Conclusions

  • * Improvements in *in vivo* snake venom research are crucial.
  • * Refining mouse assays can reduce animal use while enhancing antivenom development.
  • * Community-driven discussions are vital for advancing snakebite envenoming research and therapy.

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