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Mortality associated with polymyalgia rheumatica in the United States in the 1999-2020 period: a

R-X Huo1, Y-T Yang, J-Y Lin

  • 1Department of Rheumatology and Immunology, Guangxi Academy of Medical Sciences, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. wcc2399571052@163.com.

European Review for Medical and Pharmacological Sciences
|May 6, 2024
PubMed
Abstract

Insights

Polymyalgia rheumatica (PMR) has low mortality in the US, primarily affecting elderly women. Vigilance for complications like malignant neoplasms is crucial for timely diagnosis and treatment to reduce PMR-related deaths.

Area of Science:

  • Rheumatology
  • Epidemiology
  • Public Health

Background:

  • Polymyalgia rheumatica (PMR) is an inflammatory condition primarily affecting older adults.
  • Understanding PMR-related mortality trends is essential for public health strategies.
  • Previous studies have not comprehensively analyzed US mortality data for PMR over an extended period.

Purpose of the Study:

  • To analyze mortality patterns and leading causes of death associated with polymyalgia rheumatica (PMR) in the United States.
  • To examine trends in PMR-related deaths from 1999 to 2020 using multicause-of-death methods.

Main Methods:

  • Utilized Centers for Disease Control and Prevention (CDC) mortality data from 1999-2020.
  • Identified death certificates listing PMR (ICD-10 code) as an underlying or non-underlying cause of death.
  • Analyzed mortality rates, number of deaths, age-standardized mortality rates (ASMR), and historical trends.

Main Results:

  • A total of 15,421 PMR-related deaths occurred, with women comprising 89.8%.
  • PMR deaths were most frequent in individuals aged 70+, particularly those 80+.
  • Caucasians and Black or African Americans had the highest number of deaths; heart disease and cancer were leading causes.
  • When PMR was a multiple cause of death with malignant neoplasms, female deaths predominated, showing an upward trend in deaths but a downward trend in ASMR.

Conclusions:

  • PMR is associated with a low overall mortality rate in the US.
  • Elderly women with PMR require vigilant medical attention for potential complications, especially malignant neoplasms.
  • Timely diagnosis and treatment of comorbidities are vital to further reduce PMR-related mortality.

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