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Mia Hovgaard Jessen1,2, Merete Petersen3, Peter Derek Christian Leutscher1,2

  • 1Center for Klinisk Forskning, Regionshospital Nordjylland, Hjørring.

Ugeskrift for Laeger
|May 6, 2024
PubMed
Summary

Patients are increasingly using cannabis for chronic pain relief, but robust clinical evidence is limited due to study biases. This review examines cannabis medicine research for chronic pain, focusing on meta-analyses.

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Area of Science:

  • Pain Medicine
  • Pharmacology
  • Evidence-Based Practice

Background:

  • Growing patient interest in cannabis for chronic pain refractory to conventional analgesics.
  • Limited robust clinical evidence supporting cannabis as an adjuvant therapy.
  • Concerns regarding methodological biases in existing studies.

Purpose of the Study:

  • To review current research on cannabis medicine for chronic pain relief.
  • To critically assess the existing evidence base, particularly meta-analytic studies.
  • To identify limitations in study design, patient selection, and treatment protocols.

Main Methods:

  • Systematic review of published meta-analytic studies.
  • Analysis of research on cannabis-derived products for chronic pain.
  • Evaluation of methodological quality and biases in clinical trials.

Main Results:

  • Sparse clinical evidence for cannabis in chronic pain management.
  • Methodological limitations in study design, patient populations, and protocols hinder definitive conclusions.
  • Meta-analytic findings are often confounded by these biases.

Conclusions:

  • Current evidence for cannabis in chronic pain is sparse and potentially biased.
  • Further high-quality research with standardized protocols is needed.
  • Cannabis-derived products require rigorous evaluation before widespread adjuvant use.

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