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Updated: Jun 27, 2025

Probiotic Studies in Neonatal Mice Using Gavage
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Antibiotic duration and gastric dysmotility in preterm neonates

Liane Samira Sadder1, Larry Steven Brown2, Lindsay Roblyer3

  • 1Division of Pediatric Gastroenterology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, Texas, USA.

Journal of Pediatric Gastroenterology and Nutrition
|May 6, 2024
PubMed

Insights

Prolonged antibiotic use in preterm infants did not significantly alter gastric dysrhythmia (tachygastria). Further research with larger sample sizes is needed to confirm this finding in neonatal care.

Area of Science:

  • Neonatal physiology
  • Gastroenterology
  • Pharmacology

Background:

  • Prolonged antibiotic use is linked to neonatal feeding intolerance and functional gastrointestinal disorders (FGIDs).
  • Gastric dysrhythmia, specifically tachygastria (>4-9 cycles/min) measured by electrogastrography (EGG), is associated with FGIDs.

Purpose of the Study:

  • To investigate the relationship between prolonged antibiotic exposure and gastric dysrhythmia in preterm infants.
  • To compare weekly changes in % tachygastria between preterm infants receiving long (>48h) versus short (≤48h) antibiotic courses for early-onset sepsis evaluation.

Main Methods:

  • Prospective cohort study of 88 preterm infants (<34 weeks' gestation).
  • Weekly electrogastrography (EGG) recordings from birth to 40 weeks' postmenstrual age.
  • Mixed effects model used to assess variance in % tachygastria between antibiotic exposure groups.

Main Results:

  • No significant difference in % tachygastria was observed between the short- and long-antibiotic exposure groups across nine postnatal weeks (p=0.08).
  • Baseline characteristics were similar between the two groups.

Conclusions:

  • Early, prolonged antibiotic exposure in preterm infants may not significantly induce gastric dysrhythmia.
  • Larger studies with a "no antibiotic" control group are necessary to fully understand this relationship.
Abstract

Keywords:
electrogastrographygastric myoelectrical activitymotilityprematuretachygastria

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