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Updated: Jul 26, 2026
07:24
Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
Published on: April 8, 2013
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A meta-analysis of left ventricular dysfunction in ankylosing spondylitis
Olayiwola Bolaji1, Osejie Oriaifo2, Olanrewaju Adabale2
1Department of Internal Medicine, Rutgers University New Jersey Medical School, Newark, New Jersey, USA.
Summary
Ankylosing spondylitis patients have higher risks of left ventricular dysfunction (LVD), showing impaired heart function. This study confirms increased LVD susceptibility in AS patients, regardless of hypertension risk.
Area of Science:
- Cardiology
- Rheumatology
- Internal Medicine
Background:
- Ankylosing spondylitis (AS) is a chronic inflammatory disease impacting the spine.
- AS patients exhibit increased risk for ischemic heart disease.
- The association between AS and left ventricular dysfunction (LVD) remains debated.
Purpose of the Study:
- To investigate the risk of LVD in individuals with AS compared to the general population.
- To synthesize current evidence on cardiac function in AS patients.
Main Methods:
- Systematic literature search across five major databases and Google Scholar.
- Inclusion of 30 studies with 2933 participants meeting specific criteria.
- Meta-analysis of echocardiographic parameters and blood pressure measurements.
Main Results:
- AS patients demonstrated reduced Ejection Fraction (EF) and impaired E/A ratio.
- Prolonged deceleration time (DT) and increased isovolumetric relaxation time (IVRT) were observed in AS patients.
- No significant differences in systolic or diastolic blood pressure were found between AS patients and controls.
Conclusions:
- AS patients are more susceptible to both systolic and diastolic LVD.
- The findings highlight the importance of cardiac monitoring in AS management.
- AS does not appear to independently increase hypertension risk.
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