Invasive meningococcal disease in older adults: current perspectives and call for action

Area of Science:

• Public Health
• Epidemiology
• Immunization

Background:

• Invasive meningococcal disease (IMD) disproportionately affects adults aged 60 and older.
• Meningococcal immunization is not routinely offered to older adults, despite its importance in healthy aging.

Purpose of the Study:

• To review clinical and epidemiological aspects of IMD in older adults.
• To highlight available immunization strategies and advocate for improved access for this demographic.

Main Methods:

• An expert working group evaluated clinical and epidemiological data.
• The group aimed to raise awareness and suggest improvements for IMD burden in older individuals.

Main Results:

• IMD prevalence is increasing in unvaccinated adults aged 60+, accounting for up to 25% of cases in developed countries.
• This age group experiences the highest IMD-related mortality and significant sequelae.
• Serogroups W and Y are more common in older adults, often presenting with atypical symptoms like pneumonia or gastrointestinal issues, delaying diagnosis.

Conclusions:

• IMD in older adults is an overlooked public health issue requiring increased clinical and societal awareness.
• There is a need to reconsider IMD prevention strategies and ensure equitable access to meningococcal immunization for older adults.