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Increased central cornea thickness in localized scleroderma (morphoea).

J Serup1, L Serup

  • 1University of Copenhagen, Department of Dermatology, Denmark.

Metabolic, Pediatric, and Systemic Ophthalmology (New York, N.Y. : 1985)
|January 1, 1985
PubMed
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Localized scleroderma (morphoea) may cause increased central cornea thickness (CCT). This finding suggests morphoea impacts more than just the skin, potentially involving corneal swelling.

Area of Science:

  • Ophthalmology
  • Dermatology
  • Connective Tissue Diseases

Background:

  • Localized scleroderma, also known as morphoea, is a rare connective tissue disease.
  • The ocular manifestations of morphoea are not well-documented.
  • Central cornea thickness (CCT) is a key parameter in ocular health assessments.

Purpose of the Study:

  • To investigate whether morphoea affects central cornea thickness.
  • To compare CCT in patients with morphoea to healthy individuals.
  • To explore potential correlations between CCT and disease duration in morphoea.

Main Methods:

  • Central cornea thickness (CCT) was measured using a Haag-Streit pachymeter.
  • Seventeen patients diagnosed with localized scleroderma (morphoea) were included.

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  • Measurements were compared to a control group of healthy individuals matched for age and sex.

    • Main Results:

    • Patients with morphoea exhibited significantly increased CCT compared to controls (p < 0.01).
    • Over half of the patients (53%) had CCT values exceeding the mean + 2 standard deviations of the control group.
    • A positive correlation was observed between CCT and the duration of morphoea (correlation coefficient = 0.660, p < 0.01).

    Conclusions:

    • Morphoea is associated with increased central cornea thickness.
    • The observed increase in CCT may indicate subclinical corneal edema or alterations in corneal stroma glycosaminoglycans.
    • These findings suggest that morphoea may have systemic implications beyond cutaneous manifestations.