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Published on: July 14, 2023
Hypopituitarism and bone disease: pathophysiology, diagnosis and treatment outcomes
Amit Akirov1,2, Yaron Rudman1,2, Maria Fleseriu3
1Institute of Endocrinology, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.
Abstract:
Hypopituitarism is a rare but significant endocrine disorder characterized by the inadequate secretion of one or more pituitary hormones. The intricate relationship between hypopituitarism and bone health is a topic of growing interest in the medical community. In this review the authors explore associations between hypopituitarism and bone health, with specific examination of the impact of growth hormone deficiency, central hypogonadism, central hypocortisolism, and central hypothyroidism. Pathogenesis, diagnosis, and treatment options as well as challenges posed by osteopenia, osteoporosis, and fractures in hypopituitarism are discussed.
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