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Updated: Jun 27, 2025

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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KRAS Allelic Variants in Biliary Tract Cancers

Gordon Taylor Moffat1, Zishuo Ian Hu2, Funda Meric-Bernstam3

  • 1Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.

JAMA Network Open
|May 6, 2024
PubMed
Summary

KRAS allelic variants are common in biliary tract cancers (BTCs), particularly in perihilar and extrahepatic subtypes. The G12D variant showed the longest median overall survival, offering potential therapeutic targets for this patient group.

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