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Updated: Jun 27, 2025

Electrochemiluminescence Assays for Human Islet Autoantibodies
Published on: March 23, 2018
[Early Detection Of Type 1 Diabetes By Islet Autoantibody Screening: A Position Paper Of The Fr1daplex Project
Peter Achenbach1,2, Reinhard Berner3, Ezio Bonifacio4
1Institut für Diabetesforschung, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany.
Insights
Early detection of type 1 diabetes in children through islet autoantibody screening offers significant benefits. Research also explores teplizumab to delay disease onset, improving life for affected youth.
Area of Science:
- Pediatric Endocrinology
- Immunology
- Diabetes Research
Abstract:
This position paper is based on the authors' many years of clinical experience and basic science research on the diagnosis and treatment of children and adolescents with a presymptomatic early stage of type 1 diabetes. The benefits as well as potential disadvantages of early detection of type 1 diabetes by islet autoantibody screening are critically discussed. In addition, the perspectives of delaying the onset of the clinical metabolic disease through treatment with teplizumab are addressed. Today, we see the chance for a relevant improvement in therapeutic options and life perspectives of affected children and adolescents. Important next steps for the implementation of islet autoantibody screening in Germany are the training of pediatricians who should inform families about the screening, establishment of a few transregional laboratories that carry out the test, and expansion of regional capacities for the training and care of children with an early stage of type 1 diabetes.
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