Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Regulation

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...

Prescription, Nonprescription and Orphan Drugs

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...

Drug Control Governance: Regulatory Bodies and Their Impact

Drug Control Governance: Regulatory Bodies and Their Impact

Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...

Pharmacovigilance

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...

Drug Classes and Categories

Drug Classes and Categories

Drugs can be classified according to their chemical composition or their intended therapeutic application. For instance, anti-infective agents that possess the ability to eliminate pathogens or suppress their growth and reproduction can be grouped based on the organisms they target or their chemical structure. Furthermore, drugs can be divided into prescription, nonprescription, or controlled substances. Prescription medications, such as antibiotics, require oversight from a licensed healthcare...

Drug Biotransformation: Overview

Drug Biotransformation: Overview

Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Environmental considerations in human genomic data governance: overcoming normative challenges.

BMC medical ethics·2026

Same author

How Can the Law Keep Up? The Challenges in Regulating Health Innovations through the Lens of Embryo Research.

Journal of law and medicine·2025

Same author

Should Australian laws regulating embryo research be reformed? A call for commonwealth review.

Australian health review : a publication of the Australian Hospital Association·2025

Same author

Why Stop at a Right to Notice for AI Systems Used in Patient Care? The Need for Greater Specificity.

The American journal of bioethics : AJOB·2025

Same author

Patient-driven personal importation in the face of cost barriers to care: can we do better?

Internal medicine journal·2025

Same author

Do Doctors Have a Responsibility to Challenge the Distorting Influence of Commerce on Healthcare Delivery? The Case of Assisted Reproductive Technology.

Health care analysis : HCA : journal of health philosophy and policy·2024

Search research articles

Related Experiment Video

Updated: Jun 27, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

The Medicines Repurposing Program - a critical perspective.

Narcyz Ghinea¹

¹Philosophy Department, Faculty of Arts, Ethics and Agency Research Centre, Macquarie University, North Ryde, NSW 2109, Australia.

Australian Health Review : a Publication of the Australian Hospital Association

|May 6, 2024

Summary

The new Medicines Repurposing Program supports off-label drug uses for public health. However, commercial sponsors may unduly influence which treatments are prioritized, risking the program

More Related Videos

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

Published on: May 21, 2018

Related Experiment Videos

Last Updated: Jun 27, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

Published on: May 21, 2018

Area of Science:

Health policy
Pharmaceutical economics
Drug development

Background:

The Medicines Repurposing Program launched March 1, 2024.
Addresses off-label medicine use with significant public health benefits.
Aims to subsidize treatments lacking commercial sponsor financial incentive.

Purpose of the Study:

To provide an overview of the Medicines Repurposing Program.
To critically analyze the program's structure and potential risks.
To propose mitigation strategies for identified concerns.

Main Methods:

Review of the Medicines Repurposing Program's framework.
Critical analysis of sponsor influence on prioritization.
Development of recommendations for risk mitigation.

Main Results:

The program offers a pathway for beneficial off-label drug registration and subsidy.
Commercial sponsors retain significant influence over treatment prioritization.
Potential for bias exists due to financial incentives.

Conclusions:

The program has the potential to facilitate important public health initiatives.
Mechanisms must be in place to ensure unbiased prioritization of off-label medicines.
Mitigation strategies are needed to address sponsor influence and ensure equitable access.