Maternal smoking, consumption of alcohol, and caffeinated beverages during pregnancy and the risk of childhood brain tumors: a meta-analysis of observational studies
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View abstract on PubMed
Summary
This summary is machine-generated.Maternal passive smoking and caffeine intake during pregnancy may increase childhood brain tumor (CBT) risk. Alcohol consumption showed no significant association. Further research is needed to confirm these findings.
Area Of Science
- Epidemiology
- Oncology
- Environmental Health
Background
- Childhood brain tumors (CBTs) represent a significant health concern.
- Understanding prenatal risk factors is crucial for prevention strategies.
Purpose Of The Study
- To investigate the association between maternal smoking, alcohol, and caffeinated beverage consumption during pregnancy and the risk of childhood brain tumors (CBTs).
Main Methods
- A comprehensive meta-analysis was conducted.
- Searches were performed across major scientific databases (PubMed, Embase, Web of Science, Cochrane Library, CNKI).
- Fixed or random effects models were used for data analysis.
Main Results
- Maternal passive smoking showed a statistically significant increased risk of CBTs (OR 1.12, 95% CI 1.03-1.20).
- Caffeinated beverage consumption, particularly coffee, was associated with an increased risk of CBTs (OR 1.16, 95% CI 1.07-1.26).
- No significant association was found between maternal alcohol consumption and CBT risk.
Conclusions
- Maternal passive smoking and caffeinated beverage intake during pregnancy are potential risk factors for CBTs, especially glioma.
- Further prospective cohort studies are recommended to strengthen the evidence base.
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