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Related Experiment Video

Updated: Jun 27, 2025

Expression and Purification of Virus-like Particles for Vaccination
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Vaccine process technology-A decade of progress.

Barry Buckland1, Gautam Sanyal2, Todd Ranheim3

  • 1National Institute for Innovation in Manufacturing Biopharmaceuticals, University of Delaware, Newark, Delaware, USA.

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Summary
This summary is machine-generated.

Recent vaccine development breakthroughs, including messenger RNA and viral vector platforms, enable rapid, large-scale manufacturing. Advanced analytical tools and process technologies ensure vaccine quality and accelerate product release for improved global health.

Keywords:
analyticscell culturelipid nanoparticlemRNAmanufacturingvaccine characterization

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Area of Science:

  • Vaccinology
  • Biotechnology
  • Pharmaceutical Sciences

Background:

  • The past decade has seen transformative advancements in vaccine discovery and development.
  • The COVID-19 pandemic accelerated the adoption of novel platforms like messenger RNA (mRNA) and viral vectors, enabling mass production.
  • Significant improvements in analytical tools, equipment, and bioprocess technology have been crucial.

Purpose of the Study:

  • To highlight the impact of technological advancements on vaccine development speed and manufacturing scale.
  • To discuss the role of advanced characterization technologies in assessing vaccine quality.
  • To explore innovations enabling faster vaccine characterization and release.

Main Methods:

  • Utilized macromolecular structure-function characterization for single-particle resolution analysis.
  • Employed improved modeling and data analysis for quantitative evaluation of vaccine formulations.
  • Incorporated label-free and immunoassay technologies for antigenic site characterization and in vitro potency assays.
  • Leveraged process analytical technologies (PAT) for real-time process monitoring and optimization.

Main Results:

  • Achieved unprecedented speed in vaccine development and manufacturing scale.
  • Enabled quantitative evaluation of vaccine formulations and guided design of drug substances and products.
  • Facilitated precise assessment of critical quality attributes for novel vaccine platforms.
  • Accelerated characterization and release of vaccines through advanced analytical and molecular techniques.

Conclusions:

  • Technological innovations have revolutionized vaccine development, enhancing speed, scale, and quality assessment.
  • Advanced analytical and process technologies are critical for characterizing and manufacturing vaccines, especially those on new platforms.
  • Continued integration of new technologies promises further advancements in vaccine discovery and development for improved human health.