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Transcriptomic Profiles Associated with Experimental Placebo Effects in Chronic Pain.

Luana Colloca1,2,3,4, Evelina Mocci1,3,4, Yang Wang1,3,4

  • 1Department of Pain and Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, Maryland, USA.

Clinical Pharmacology and Therapeutics
|May 7, 2024
PubMed
Summary
This summary is machine-generated.

This study identified 667 genes linked to placebo effects in chronic pain patients, with most upregulated genes correlating with stronger placebo responses. These findings highlight key biological pathways influencing placebo responsivity.

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Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • Placebo effects are a significant factor in pain management but their underlying gene expression networks are not well understood.
  • Identifying molecular correlates of placebo responsivity can lead to personalized pain treatment strategies.

Purpose of the Study:

  • To identify transcriptomic profiles associated with placebo responsivity in individuals with chronic pain.
  • To investigate the biological processes and gene expression patterns linked to placebo effects.

Main Methods:

  • Chronic pain participants underwent a conditioning paradigm to elicit placebo effects, reporting pain via a visual analog scale (VAS).
  • RNA sequencing was performed on blood samples to identify differentially expressed genes (DEGs) associated with placebo effects.
  • Unbiased enrichment analyses were used to determine biological pathways implicated in placebo responsivity.

Main Results:

  • Out of 10,700 protein-coding genes, 667 were significantly associated with placebo effects (FDR <0.05).
  • 97% of upregulated genes correlated with larger placebo effects.
  • Six validated genes (CCDC85B, FBXL15, HAGH, PI3, SELENOM, TNFRSF4) showed significant positive correlation with placebo effects.
  • DEGs were enriched in RNA metabolism, ribosome biogenesis, and regulation of SLITs/ROBOs, and Huntington's disease pathways.

Conclusions:

  • Gene expression profiles are significantly associated with placebo responsivity in chronic pain.
  • Alterations in RNA metabolism, ribosome biogenesis, and related pathways may influence an individual's susceptibility to placebo effects.
  • Further research is needed to validate these findings and explore the molecular mechanisms of placebo effects in pain management.