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Related Experiment Video

Updated: Jun 20, 2026

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

Microphysiological systems as models for immunologically 'cold' tumors.

Daniela Gaebler¹, Stephanie J Hachey¹, Christopher C W Hughes^1,2

¹Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, United States.

Frontiers in Cell and Developmental Biology

|May 7, 2024

Summary

This summary is machine-generated.

Microfluidic systems are crucial for understanding the tumor microenvironment (TME) in

Keywords:

bioengineering cancer immunology immunosuppressive microfluidic therapeutic development tissue engineering tumor microenvironment tumor on chip

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Area of Science:

Oncology
Immunology
Biotechnology

Background:

The tumor microenvironment (TME) significantly influences cancer progression and therapeutic resistance.
Immunologically 'cold' tumors present challenges due to low immune cell infiltration and immunosuppressive factors.
Current models struggle to fully replicate the complex TME interactions.

Purpose of the Study:

To highlight the role of microfluidic systems in studying the TME.
To review microfluidic models for dissecting cellular interactions in 'cold' tumors.
To emphasize the need for advanced TME models for targeted immunotherapies.

Main Methods:

Review of current literature on microfluidic devices for TME research.
Analysis of microfluidic systems designed to model tumor-stromal and tumor-immune interactions.
Focus on applications in immunologically 'cold' tumors.

Main Results:

Microfluidic devices offer superior recapitulation of TME complexity compared to traditional models.
These systems enable precise control and real-time monitoring of cellular crosstalk.
Microfluidics facilitates detailed investigation of immune, stromal, and cancer cell dynamics.

Conclusions:

Microfluidic platforms are essential tools for advancing TME research in 'cold' tumors.
Understanding TME intricacies via microfluidics can lead to novel targeted immunotherapies.
Developing better TME models is key to overcoming immunotherapy resistance and improving patient outcomes.