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Linking elevated HbA1c with atherogenic lipid profile among high risk cardiovascular patients at Qassim, Saudi Arabia

Rihab Akasha1, Saheem Ahmad1, Rnada Abdeen1

  • 1Department of Clinical Laboratory Sciences,College of Applied Medical Sciences,University of Hail, Saudi Arabia.

Bioinformation
|May 7, 2024
PubMed

Insights

Glycated hemoglobin (HbA1c) correlates with unhealthy lipid profiles, including LDL-C and non-HDL-C. This highlights the importance of glycemic control for reducing cardiovascular disease risk in diabetic patients.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Clinical Chemistry

Background:

  • Elevated glycated hemoglobin (HbA1c) is linked to increased cardiovascular disease (CVD) risk.
  • An atherogenic lipid profile, characterized by abnormal cholesterol and triglyceride levels, also contributes to CVD.
  • Understanding the relationship between HbA1c and lipid profiles is crucial for CVD risk stratification.

Purpose of the Study:

  • To investigate the correlation between HbA1c levels and various atherogenic lipid profile parameters.
  • To assess the potential of HbA1c as a predictor of dyslipidemia in a diverse age group.

Main Methods:

  • Retrospective cross-sectional study involving 83 participants (ages 14-77).
  • Analysis of fasting lipid profiles (total cholesterol, triglycerides, HDL-C, LDL-C) and HbA1c levels from venous blood samples.
  • Calculation of non-HDL cholesterol and LDL/HDL ratio.
  • Statistical analysis to determine correlations between HbA1c and lipid parameters.

Main Results:

  • Significant positive correlations were found between HbA1c and LDL-C, non-HDL-C, and the LDL/HDL ratio.
  • Total cholesterol levels showed a positive correlation with HbA1c, despite no significant group differences.
  • High-density lipoprotein cholesterol (HDL-C) also exhibited direct correlations with HbA1c.
  • HbA1c showed no correlation with clinical characteristics, except for age.

Conclusions:

  • HbA1c is a significant predictor of dyslipidemia in diabetic patients.
  • A strong association exists between elevated HbA1c and an atherogenic lipid profile.
  • Effective glycemic control is vital for mitigating cardiovascular disease risk in individuals with diabetes.

Keywords:
Atherogenic LipoproteinsHbA1cLDL cholesterolLipid ProfileNon-HDL cholesterol

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