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PROSTATE CELL HETEROGENEITY AND CXCL17 UPREGULATION IN MOUSE STEROID HORMONE IMBALANCE
Samara V Silver1,2, Kayah J Tucker1,2, Renee E Vickman3
1Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA.
Biorxiv : the Preprint Server for Biology
|May 7, 2024
Summary
Steroid hormone imbalance in mice causes specific macrophage changes in the prostate, leading to foam cell formation. Epithelial cells release CXCL17, attracting macrophages and potentially driving benign prostatic hyperplasia (BPH) progression.
Area of Science:
- Urology
- Immunology
- Cell Biology
Background:
- Benign prostatic hyperplasia (BPH) is a common age-related condition causing urinary symptoms, linked to hormonal imbalance and inflammation.
- Previous research indicated increased macrophages in the prostate lumen, differentiating into foam cells under steroid hormone imbalance.
- The current study investigates prostate cellular heterogeneity and foam cell transcriptomics in a mouse model.
Conclusions:
- Steroid hormone imbalance induces specific macrophage subsets and luminal foam cell accumulation in the prostate.
- Prostate foam cells exhibit a pro-pathological gene expression profile.
- CXCL17-mediated macrophage migration is a key initiating event in this BPH model.
