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MATRIN3 deficiency triggers autoinflammation via cGAS-STING activation.

Zohirul Islam1, Ahsan Polash2, Masataka Suzawa2

  • 1Integrative Immunobiology Section, Laboratory of Immune System Biology (LISB), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH); Bethesda, Maryland 20892, USA.

Biorxiv : the Preprint Server for Biology
|May 7, 2024
PubMed
Summary

Perturbing MATRIN3 (MATR3) protein elevates interferon-stimulated genes (ISGs), activating a pathway linked to inflammatory diseases and amyotrophic lateral sclerosis (ALS). This finding suggests new diagnostic and therapeutic strategies for ALS.

Keywords:
R-loopsRNA-DNA hybridsRNA-binding proteinsgene expression programsgene regulatory networksinflammationinterferon-stimulated genesnonsense-mediated decaypost-transcriptional regulationsplicing

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