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Updated: Jun 26, 2026
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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
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Microstructural Mapping of Neural Pathways in Alzheimer's Disease using Macrostructure-Informed Normative Tractometry
Yixue Feng1, Bramsh Q Chandio1, Julio E Villalon-Reina1
1Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States.
Biorxiv : the Preprint Server for Biology
|May 7, 2024
Summary
This study introduces Macrostructure-Informed Normative Tractometry (MINT) to analyze brain white matter changes in mild cognitive impairment (MCI) and dementia. MINT offers a more comprehensive understanding of neural pathway alterations than traditional methods.
Area of Science:
- Neuroimaging
- Brain Microstructure and Macrostructure Analysis
Background:
- Diffusion MRI is sensitive to brain tissue microstructure and useful for detecting degenerative diseases.
- Current methods often analyze averaged measures, neglecting fiber geometry, which may limit interpretation.
Conclusions:
- MINT provides a more nuanced approach to understanding brain changes in neurodegenerative diseases by integrating macrostructural and microstructural information.
- Jointly modeling tract shape and microstructure enhances the interpretation of diffusion MRI findings in conditions like MCI and dementia.
